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Specimen handling to prevent the ex vivo oxidation of rGSH is impractical, and direct measurement of rGSH in vivo is not feasible outside of a research setting
Originally developed for type 2 diabetes management (as Ozempic), it earned FDA approval specifically for weight loss under the brand name Wegovy in 2021
More significant weight losssuch as losing 5% or more of your initial body weighttypically occurs over a longer period, often within 3 to 6 months of consistent use
However, in the other 12 CVOTs of SGLT2is, allocation to a SGLT2i was not significantly associated with lower limb amputations (RR, 1.06
Critically, this does not affect the glucagon response to hypoglycemia as this effect is also glucose-dependent
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